Publications by authors named "A Weihs"
Study Objectives: Poor sleep may play a role in the risk of dementia. However, few studies have investigated the association between polysomnography (PSG)-derived sleep architecture and dementia incidence. We examined the relationship between sleep macro-architecture and dementia incidence across five US-based cohort studies from the Sleep and Dementia Consortium (SDC).
View Article and Find Full Text PDFBackground: This study examines the relationship between obstructive sleep apnea severity, sleep position, and body weight, particularly focusing on the negative impact of sleeping in a supine position combined with being overweight in a population-based sample.
Methods: The Apnea-Hypopnea Index (AHI) was utilized as a marker of OSA severity and sleep position from a standardized overnight polysomnography. Participants were categorized by body mass index (BMI) (kg/m) into normal weight/underweight (<25) and overweight (≥25).
Article Synopsis
- Understanding how antidepressants work at a molecular level can lead to better therapies that people tolerate well.
- The study analyzed DNA methylation changes linked to antidepressant use across multiple cohorts, using blood samples and data collected between 2006 and 2011.
- Results showed specific DNA regions with increased methylation in individuals using antidepressants, with findings suggesting connections to brain-related genes and providing insights for further research on treatment effectiveness.
Objective: Cumulative evidence indicates that childhood maltreatment (CM) is associated with sleep disturbances possibly suggesting sleep apnea. However, the relation between CM and objective measures of sleep apnea as determined by polysomnography (PSG) has not yet been assessed.
Methods: Using a cross-sectional design and based on PSG measurements from N = 962 subjects from the SHIP-Trend general population study, we used linear regression models to investigate the relationship between apnea-hypopnea (AHI) and oxygen desaturation index (ODI) and Epworth sleepiness scale (ESS) metrics and the Childhood Trauma Questionnaire (CTQ).
Article Synopsis
- * The study analyzed the relationship between mRNA levels, cortisol levels, childhood maltreatment, and depressive symptoms using data from the Study of Health in Pomerania (SHIP) with a sample size of 203 participants.
- * Findings included notable associations between gene methylation at certain sites and both childhood maltreatment and depression, suggesting potential pathways for personalized depression treatment and drug development.