Publications by authors named "A Weigand"
Objectives: Social and structural determinants of health (SSDoH) have been linked to racial disparities in Alzheimer's disease and related dementias (ADRD). Research has established that living in an environment with greater economic stability (ES) or healthcare access (HCA) is associated with better baseline cognition, but the interactive effects between these distinct SSDoH on cognition over time have not been studied. Therefore, the present study examined the independent and interactive effects of ES and HCA on 10-year change in cognitive functioning within a large sample of racially diverse community-dwelling older adults.
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- - Ketamine is shown to be an effective antidepressant that influences brain circuits by targeting the glutamatergic system, particularly affecting negative emotional processing.
- - A study involving 75 healthy participants examined the effects of ketamine alone and in combination with lamotrigine, which inhibits glutamate release, revealing that lamotrigine can block ketamine's impact on brain connectivity.
- - Results indicated that while ketamine immediately altered brain activity and connectivity, particularly in the Default Mode Network, lamotrigine prevented some of these changes, suggesting the importance of glutamatergic transmission in the antidepressant effects of ketamine.
Introduction: Subjective cognitive decline (SCD) may be an early marker of Alzheimer's disease (AD) pathology. Until recently, it was impossible to measure biomarkers specific for α-synuclein pathology; therefore, its association with subjective reports of cognitive decline is unknown.
Methods: Alzheimer's Disease Neuroimaging Initiative participants without dementia (n = 918) were classified as positive or negative for amyloid beta (Aβ+ or Aβ-) and α-synuclein (α-syn+ or α-syn-) biomarkers.
Objectives: Post-traumatic stress disorder (PTSD) and subjective cognitive decline (SCD) are independent risk factors for Alzheimer's disease (AD) and dementia, but the association of their interaction on AD biomarkers have yet to be characterized. This study aimed to examine the impact of PTSD on the association between SCD and tau and amyloid positron emission tomography (PET) as well as global cognition in older Veterans.
Method: This study included 87 Vietnam-Era Veterans without dementia (42 with PTSD; 45 without PTSD) from the Department of Defense-Alzheimer's Disease Neuroimaging Initiative.