Publications by authors named "A Way"
Article Synopsis
- Spondyloarthritis (SpA) is a common condition among patients with inflammatory bowel disease (IBD), affecting up to 39% of individuals but lacks well-defined risk factors.
- The study involved assessing 588 IBD patients using two validated questionnaires to identify SpA symptoms, revealing significant positive screenings for SpA among these patients.
- Key risk factors for positive SpA screens included being female, older age, a history of smoking, bowel surgery, and exposure to biologic treatments, with a concerning number of undiagnosed cases identified.
Article Synopsis
- Spondyloarthritis (SpA) is a common issue for patients with inflammatory bowel disease (IBD), and using specific screening tools could help identify it earlier and improve treatment.
- A study analyzed 669 IBD patients using two questionnaires (DETAIL and IBIS-Q) to check for SpA symptoms; many patients screened positive, with more showing axial symptoms rather than peripheral issues.
- The results highlighted that a significant number of patients with IBD might have undiagnosed SpA, particularly with the IBIS-Q being more effective in identifying potential cases, indicating a need for better rheumatology referrals for these patients.
Significant aggregation challenges were encountered during the manufacturing processing of an immunocytokine diabody fusion protein. To mitigate this issue and reduce aggregates in the purification process, a variety of depth filters were evaluated for harvest clarification and post-Protein A intermediate filtration. Emphaze™ AEX Hybrid Purifier, a fully synthetic quaternary amine functionalized anion exchange (AEX) nonwoven filter, was found to be particularly effective in removing aggregates during both harvest clarification and post-Protein A intermediate filtration steps.
View Article and Find Full Text PDFDevelopment and implementation of optimized endogenous contrast sequences for delineation in adaptive radiotherapy on a 1.5T MR-linear-accelerator: a prospective R-IDEAL stage 0-2a quantitative/qualitative evaluation of site-specific quality-assurance using a 3D T2 fat-suppressed platform for head and neck cancer.
J Med Imaging (Bellingham)
November 2023
Article Synopsis
- The study aimed to enhance segmentation accuracy in head and neck cancer radiotherapy by optimizing a specific type of MRI sequence known as SPAIR for use with a 1.5T MR-Linac.
- After testing several sequences, three viable SPAIR sequences were analyzed for various metrics, leading to the identification of a top-performing sequence for better delineation of tumors and lymph nodes.
- Ultimately, the research provided an optimized imaging sequence for Unity MR-Linac users and established a new pathway for objectively assessing image quality in MRI, which can benefit future protocols.
A Rare Case of Infliximab-Induced Small Vessel Vasculitis With Renal Involvement.
J Investig Med High Impact Case Rep
November 2023
There are few cases in the literature demonstrating vasculitis induced by tumor necrosis factor-α. There exist even fewer cases of systemic inflammation involving the skin, nerves, and kidneys. Here, we present a novel case of a 27-year-old man with Crohn disease refractory to multiple medications, most recently treated with infliximab.
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