A Virtual Music Mindfulness Tool for Individuals of African descent during COVID-19.

Mental health disparities result from complex factors, including differential diagnoses, lack of access to standard mental health treatments, and inconsistent application of treatments when care is accessed. The COVID-19 pandemic exacerbated these disparities as marginalized groups had less access to testing and care while having higher infection rates. Community-based forms of care, such as music and mindfulness, are affordable and accessible options that can potentially address present mental health disparities.

Changing Treatment and Metastatic Disease Patterns in Patients with EGFR Mutated NSCLC: An Academic Thoracic Medical Investigator's Consortium Registry Analysis.

Introduction: Osimertinib is now a standard first-line (1L) therapy for EGFR-mutated (EGFRm) advanced NSCLC. We aimed to characterize patterns of therapy and longitudinal risk of brain and liver metastasis in a cohort of EGFRm NSCLC.

Methods: Patients with metastatic EGFRm NSCLC who received 1L systemic therapy at sites within the Academic Thoracic Medical Investigator's Consortium were included; demographic and clinical data including treatment patterns were described.

Electron-rich anilines as cleavable linkers for peptides.

We report the development of a new electron-rich aniline (ERA)-based cleavable linker. Anilines can be incorporated into peptides during SPPS and are stable to most reaction conditions. ERA-containing peptides can be cleaved rapidly in the presence of oxidants, such as DDQ, CAN, and NaIO, in 30 min at room temperature.

Where does attention-deficit/hyperactivity disorder fit in the psychopathology hierarchy? A symptom-focused analysis.

Modern psychopathology classification systems position attention-deficit/hyperactivity disorder (ADHD) with different groups of conditions, either with externalizing or neurodevelopmental. As such, the optimal placement of ADHD in modern classification systems remains unclear. We advanced the literature by mapping ADHD symptoms onto three transdiagnostic psychopathology spectra-externalizing, neurodevelopmental, and internalizing-and their symptoms.

Contribution of rare chromosome 22q11.2 copy number variants to non-syndromic bicuspid aortic valve.

Background: Bicuspid aortic valve (BAV) is the most common congenital heart defect in adults, often leading to complications such as thoracic aortic aneurysms and aortic stenosis. While BAV is frequently associated with 22q11.2 deletion syndrome (22q11.