Publications by authors named "A Warsy"
Objectives: To determine the allelic frequencies and effects of genotypic variations in cytokine gene polymorphisms in a Saudi Arabian population.
Methods: This cross-sectional study involved 41 patients with Primary Sjögren's syndrome (pSS) and 71 healthy controls between October 2018 and May 2019. Single nucleotide polymorphisms genotyping was performed using the SEQUENOM MassARRAY System, targeting nine polymorphisms in different cytokine genes.
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that causes multi-articular synovitis. The illness is characterized by worsening inflammatory synovitis, which causes joint swelling and pain. Synovitis erodes articular cartilage and marginal bone, resulting in joint deterioration.
View Article and Find Full Text PDFUnlabelled: Rheumatoid arthritis (RA) is a complex, multifactorial disorder with an autoimmune etiology. RA is highly heritable and is associated with both human leucocyte antigen (HLA) and non-HLA genes. We investigated the associations of 33 single nucleotide polymorphisms (SNPs) with RA in the Saudi population.
View Article and Find Full Text PDFGlobal Transcriptional Profiling of Granulosa Cells from Polycystic Ovary Syndrome Patients: Comparative Analyses of Patients with or without History of Ovarian Hyperstimulation Syndrome Reveals Distinct Biomarkers and Pathways.
J Clin Med
November 2022
Article Synopsis
- Ovarian hyperstimulation syndrome (OHSS) is a complication often linked with polycystic ovarian syndrome (PCOS), a common endocrine disorder in women during their reproductive years.
- Researchers analyzed the RNA from granulosa cells of PCOS patients, comparing those with a history of OHSS to those without, and discovered 59 genes that were significantly altered, indicating differences in cellular processes and inflammation related to OHSS.
- This study represents the largest analysis of Saudi PCOS cases using transcriptomic methods, highlighting important gene networks and pathways associated with the condition, suggesting a need for further research to validate these findings.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency disorder affecting over 400 million individuals worldwide. G6PD protects red blood cells (RBC) from the harmful effects of oxidative substances. There are more than 400 G6PD mutations, of which 186 variants have shown to be linked to G6PD deficiency by decreasing the activity or stability of the enzyme.
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