Publications by authors named "A Wadeson"
Objective: Management options for vestibular schwannoma include microsurgery (MS), stereotactic radiosurgery (SRS), and watch, wait, and rescan (WWR). This study aimed to evaluate changes in patient and disease-specific quality of life (QoL) outcomes over time, comparing each treatment modality in a matched cohort.
Methods: A prospective cohort study recruited adult patients with sporadic vestibular schwannomas ≤ 3 cm in size undergoing treatment between January 2012 and April 2022 in a single tertiary referral center.
Background: Nonauditory symptoms can be a prominent feature in patients with sporadic vestibular schwannoma (VS), but the cause of these symptoms is unknown. Inflammation is hypothesized to play a key role in the growth and symptomatic presentation of sporadic VS, and in this study, we investigated through translocator protein (TSPO) positron emission tomography (PET) whether inflammation occurred within the "normal appearing" brain of such patients and its association with tumor growth.
Methods: Dynamic PET datasets from 15 patients with sporadic VS (8 static and 7 growing) who had been previously imaged using the TSPO tracer [C]()-PK11195 were included.
Article Synopsis
- The study investigates the potential long-term effects of radiation treatment, particularly focusing on the rare occurrence of radiation-induced vestibular schwannomas (VSs) among patients who received radiation that covered the posterior fossa.* -
- A review of eight cases revealed that patients had a median age of 15 years at the time of radiation and were diagnosed with VS a median of 51 years later, with some tumor characteristics noted, such as adherence to the facial nerve.* -
- The findings suggest that while the occurrence of radiation-induced VS is rare, more research is needed to understand its causative relationship with radiation exposure and to improve management strategies for affected patients.*
Objective: The aim of this study was to describe the natural history of incidental benign-appearing notochordal lesions of the skull base with specific attention to features that can make differentiation from low-grade chordoma more difficult, namely contrast uptake and bone erosion.
Methods: In this retrospective case series, the authors describe the clinical outcomes of 58 patients with incidental benign-appearing notochordal lesions of the clivus, including those with minor radiological features of bone erosion or contrast uptake.
Results: All lesions remained stable during a median follow-up of almost 3 years.
Objective: Translabyrinthine excision of a vestibular schwannoma is associated with acute vestibular failure. Preoperative intratympanic gentamicin (ITG) injections can improve objective balance function after surgery but its clinical benefits remain to be established.
Methods: Adult patients undergoing translabyrinthine removal of a vestibular schwannoma between January 2014 and February 2018 underwent preoperative vestibular function testing.