Publications by authors named "A W Sim"
Article Synopsis
- The study examines the link between liver disease type (alcohol-related vs non-alcohol-related) and 6-week mortality following acute variceal bleeding (AVB) in patients with cirrhosis.
- Researchers analyzed data from two large cohorts in the U.S. and Singapore, including 1,349 patients, and found that non-ALD patients had a significantly higher risk of mortality compared to ALD patients.
- Incorporating the etiology of cirrhosis into existing mortality prediction models improved accuracy, highlighting the importance of considering the type of liver disease for patient care.
Article Synopsis
- The NOTCH2NLC gene is linked to several neurological disorders through expansions of GGC repeats in its 5' untranslated region, which can lead to conditions like Parkinson's, dementia, and tremors.
- The study used cellular models and CRISPR-Cas9 engineered mice with specific GGC repeat variations to investigate the effects of these repeats, particularly focusing on those with serine insertions.
- Results showed that a specific intermediate repeat with serine insertion caused mitochondrial dysfunction and neurotoxicity, leading to PD-like symptoms in mice, including neuronal loss and behavioral impairments.
Purpose: To evaluate the acceptability and feasibility of a consumer co-designed telehealth intervention which aimed to reduce claimant distress by providing pain management strategies, informational and social support to people who had made a compensation claim following road traffic musculoskeletal injury.
Methods: Eleven claimant participants who were at risk of a poor outcome completed the intervention in a one-on-one setting with the same clinician delivering the program across all sessions.They were interviewed about their experience (acceptability and feasibility including the use of telehealth).