Erlotinib Treatment in Colorectal Cancer Suppresses Autophagy Based on Mutation.

The gene is mutated in approximately 45% of colorectal cancer patients. There are currently very few targeted treatments or therapies equipped to directly inhibit due to its unusual structural intricacies. Erlotinib, an EGFR inhibitor, has previously been demonstrated to reduce cell viability by inducing autophagy in lung cancer cell lines with varying EGFR mutations.

Impact of carbamazepine on SMARCA4 (BRG1) expression in colorectal cancer: modulation by KRAS mutation status.

SMARCA4 is a gene traditionally considered a tumor suppressor. Recent research has however found that SMARCA4 likely promotes cancer growth and is a good target for cancer treatment. The drug carbamazepine, an autophagy inducer, was used on colorectal cancer cell lines, HCT1116 and Hke3 (KRAS mutant and wildtype).

Bioimpedance technique for monitoring cerebral artery stenosis in a 3D numerical model of the head.

Insufficient blood supply to the brain causes a transient ischemic attack (TIA) or a stroke. One of the causes to insufficient blood supply is cerebral artery stenosis. In this study, the feasibility of bioimpedance for monitoring such stenosis was analyzed.

Fiber Fourier optics.

The Fourier transform of a coherent optical image can be evaluated physically by use of a single lens plus free-space propagation, thereby providing the basis for the field of Fourier optics. I point out that one can similarly evaluate the discrete Fourier transform of a sampled or pixelated optical array physically by passing the discrete array amplitudes through a network of single-mode fibers or optical waveguides. A passive optical network that evaluates the fast Fourier transform of a coherent array can be fabricated by use of (N/2)log(2)[N] optical 3-dB couplers plus small added phase shifts.