Ruthenium-Catalyzed Intramolecular Allene-alkyne Cascade Cyclization: Access to the Sulfone-cyclopenta[]naphthalene Core.

A ruthenium-catalyzed intramolecular cascade cyclization of allene-alkyne has been achieved. This method offers a streamlined and atom-economical approach for the construction of sulfone bearing 1-cyclopenta[]naphthalenes, an important structural scaffold that exists in biologically active compounds. Our approach, backed by mechanistic insights from deuterium labeling, DFT calculations, and potential for reaction scale-up, presents synthetic chemists with an invaluable tool for efficiently producing a distinct carbon framework in a one-pot manner.

Comparison of Oral Hygiene and Gingival Outcomes in Children With Special Care Needs Using Powered or Manual Toothbrushes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Aim: This systematic review and meta-analysis (SRMA) compares oral hygiene and gingival outcomes in children with special care needs (CSCNs) using powered or manual toothbrushes.

Material And Methods: Two authors searched articles using PubMed and Cochrane library; the search was extended to other databases to include publications until July 2024. RCTs available in English were included.

Enhanced brain tumor detection and segmentation using densely connected convolutional networks with stacking ensemble learning.

- Brain tumors (BT), both benign and malignant, pose a substantial impact on human health and need precise and early detection for successful treatment. Analysing magnetic resonance imaging (MRI) image is a common method for BT diagnosis and segmentation, yet misdiagnoses yield effective medical responses, impacting patient survival rates. Recent technological advancements have popularized deep learning-based medical image analysis, leveraging transfer learning to reuse pre-trained models for various applications.

Red-light mediated formylation of indoles using a helical carbenium ion as a photoredox catalyst.

Low-energy photoredox catalysis has gained significant attention in developing organic transformations due to its ability to achieve high penetration depth and minimum health risks. Herein, we disclose a red-light ( = 640 nm)-mediated C-3 formylation of indoles utilizing a helical carbenium ion as a photocatalyst and 2,2-dimethoxy-,-dimethylethanamine as a formylating source. These protocols exhibit a broad substrate scope under mild conditions with efficient scalability for the synthesis of C-3 formylated indoles.