Biomarkers.

Background: African American (AA) persons have a higher Alzheimer's disease (AD) prevalence and report more perceived stress than White persons. Our previous cross-sectional study (JAD, 2020, 77:843-853) demonstrated an association between self-reported stress levels and cerebrospinal fluid (CSF) AD biomarkers. Using a biracial cohort, the current study investigates the association between stress and longitudinal CSF AD biomarkers over time.

Biomarkers.

Background: Older African American (AA) and Hispanic American (HA) adults have a higher risk for Alzheimer's disease and related dementias (ADRD) compared to non-Hispanic white (NHW) adults. AA and HA persons may also develop disease at younger ages with more rapid progression. Vascular disease, including cerebral small vessels, manifest by white matter hyperintensity (WMH) lesions, is more prevalent in AA and HA.

Biomarkers.

Background: Older African American (AA) and Hispanic American (HA) adults have a higher risk for Alzheimer's disease and related dementias (ADRD) than older non-Hispanic white (NHW) adults. Adverse experiences like stress and discrimination may contribute to the higher vascular disease burden observed in AA and HA persons. Cerebrovascular disease reflected by white matter hyperintensity (WMH) lesions on magnetic resonance imaging (MRI) may affect ADRD risk in older AA and HA adults.

Provincial distribution of unintended pregnancy and its associated factors in Sierra Leone.

Background: Unintended pregnancy is a significant public health concern in Sierra Leone, with far-reaching consequences for both mothers and children. This issue impacts individual well-being, strains healthcare systems, and hinders socioeconomic development. This study examined the prevalence and factors associated with unintended pregnancy in Sierra Leone.

Socioeconomic and geographical inequalities in polio immunisation coverage among two-year-olds in Sierra Leone, 2008-2019.

Background: Polio, a debeilitating and potentially life-threatening disease, continues to pose a risk to young children globally. While vaccination offers a powerful shield, its reach is not always equal. This study explores socioeconomic and geographical inequalities in polio immunisation coverage among two-year-olds in Sierra Leone between 2008 and 2019.