Three Synchronous Non-melanoma Skin Cancers of the Head and Neck: A Case Report and Literature Review.

Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are the most common non-melanoma skin cancers, with exposure to ultraviolet (UV) light being the most important risk factor. These tumors usually affect older individuals with fair complexions. The co-occurrence of two or more non-melanoma skin cancers is a rare clinical event, the diagnosis of which rests on pathologic examination of the excised tumors.

Teaching pathology differently: Comparision between three diverse teaching learning methods.

Background: Pathology is a subject which demands deep understanding of the fundamentals. This entails regular reading, discussion, viewing the organs and slides to understand the evolution of the disease. For a sound understanding of the subject a robust clinicopathological correlation is a must.

Glomerulitis in T cell-mediated renal allograft rejection and antibody-mediated rejection histology in the absence of donor-specific antibodies heralds a similar clinico-morphologic pattern of injury to an antibody-mediated rejection: A systematic review.

The morphologic finding of transplant glomerulitis (g) forms important evidence of microvascular injury. Besides antibody-mediated rejection (ABMR), this morphological feature is also seen in acute cellular rejection (ACR) and vasculitis but not included in the grading criteria for cellular rejection. A systematic review was thus conducted to summarize the current evidence and shed light on the quantum of impetus to be given to this finding when encountered during evaluation of renal biopsies.

Adenovirus: a possible trigger for IgA vasculitis in children.

IgA vasculitis (IgAV), also called Henoch-Schönlein purpura (HSP), is an immune complex vasculitis characterised by IgA1-dominant immune deposits affecting small vessels (predominantly capillaries, venules or arterioles). It often involves the skin and gastrointestinal tract, frequently causes arthritis and rarely causes vasculitis in the kidney indistinguishable from IgA nephropathy. It usually presents as a purpuric non-blanching rash mostly on the lower limbs, although it may extend to the upper limbs and the trunk, and more rarely to the face.

Maraviroc enhances Bortezomib sensitivity in multiple myeloma by inhibiting M2 macrophage polarization via PI3K/AKT/RhoA signaling pathway in macrophages.

Background: Multiple myeloma (MM) is a malignancy where drug resistance often leads to relapse or refractory disease. Chemokine receptor 5 (CCR5) has emerged as a novel therapeutic target. However, the role of CCR5-antagonist Maraviroc (MVC) in M2 macrophage polarization and its potential to enhance Bortezomib sensitivity in MM has not been fully explored.