Publications by authors named "A W Horsley"
Article Synopsis
- Musculoskeletal issues are common among people with cystic fibrosis (CF), but there’s a lack of accurate data on how often these problems occur and their effects.
- A study surveyed 489 adults from UK CF centers, finding that nearly half experienced musculoskeletal symptoms that impacted daily activities, with back and knee pain being especially prevalent.
- The research concluded that while musculoskeletal symptoms are frequent in CF, they are often not caused by inflammatory arthritis, indicating a need for better understanding and management of these issues.
Background: People hospitalised for coronavirus disease 2019 (COVID-19) have elevated incidence of diabetes. However, it is unclear whether this is due to shared risk factors, confounding or stress hyperglycaemia in response to acute illness.
Methods: We analysed a multicentre prospective cohort study (PHOSP-COVID) of people ≥18 years discharged from NHS hospitals across the United Kingdom following COVID-19.
Airway constriction and blockage in obstructive lung diseases cause ventilation heterogeneity and create barriers to effective drug deposition. Established computational particle-deposition models have not accounted for these impacts of disease. We present a new particle-deposition model that calculates ventilation based on the resistance of each airway, such that ventilation responds to airway constriction.
View Article and Find Full Text PDFBackground: In patients with coronavirus disease 2019 (COVID-19) requiring supplemental oxygen, dexamethasone reduces acute severity and improves survival, but longer-term effects are unknown. We hypothesised that systemic corticosteroid administration during acute COVID-19 would be associated with improved health-related quality of life (HRQoL) 1 year after discharge.
Methods: Adults admitted to hospital between February 2020 and March 2021 for COVID-19 and meeting current guideline recommendations for dexamethasone treatment were included using two prospective UK cohort studies (Post-hospitalisation COVID-19 and the International Severe Acute Respiratory and emerging Infection Consortium).