Publications by authors named "A W Helms"
Background: Females with hypertrophic cardiomyopathy present at a more advanced stage of the disease and have a higher risk of heart failure and death. The factors behind these differences are unclear. We aimed to investigate sex-related differences in clinical and genetic factors affecting adverse outcomes in the Sarcomeric Human Cardiomyopathy Registry.
View Article and Find Full Text PDFPurpose Of Review: To summarize the available data on the use of immunosuppression therapies for the management of hot phases of disease and recurrent myocarditis in patients with desmoplakin cardiomyopathy (DSP-CMP).
Recent Findings: Occurrence of myocarditis episodes has been associated with worsening of outcomes in DSP-CMP. Multiple case reports and small case series have described potential benefit in using anti-inflammatory and immunosuppressive medications for the treatment of those episodes.
Flipping indirect defense: chemical cues from natural enemies mediate multitrophic interactions.
Curr Opin Insect Sci
December 2024
Plants and invertebrates use chemical signals and cues to construct information about their environment. It is well reviewed that chemical signals play key roles in interactions between conspecific insects, such as sex pheromones for finding mates, and that plants transmit chemical signals to recruit natural enemies that kill herbivores. However, it is also known that chemicals emitted by natural enemies can influence insect herbivore physiology and behavior.
View Article and Find Full Text PDFArticle Synopsis
- - Hypertrophic cardiomyopathy (HCM) was traditionally seen as caused by rare, high-risk single-gene changes, but new research indicates common low-risk variants (LowSVs) also play a significant role in the disease.
- - In a study of over 6000 patients, 12 LowSVs were discovered, which are relatively common in the general population and more prevalent in HCM patients, suggesting they may influence disease severity and risk.
- - While LowSVs alone are linked to a later onset of HCM and fewer complications, their presence alongside more severe genetic variants increases health risks significantly.
Article Synopsis
- The study focuses on understanding the complex patterns of -glycosylation in mucin domain proteins, which are important in diseases like cancer.
- Researchers are developing new methods to analyze these glycoproteins due to the difficulties presented by their diverse glycosylation structures.
- They combine the use of a targeted protease and ultraviolet photodissociation mass spectrometry to identify and map glycoforms of proteins like TIM-1, MUC-1, and MUC-16, further revealing glycosylation trends in these proteins.