Emerging opportunities for intact and native protein analysis using chemical proteomics.

Chemical proteomics has advanced small molecule ligand discovery by providing insights into protein-ligand binding mechanism and enabling medicinal chemistry optimization of protein selectivity on a global scale. Mass spectrometry is the predominant analytical method for chemoproteomics, and various approaches have been deployed to investigate and target a rapidly growing number of protein classes and biological systems. Two methods, intact mass analysis (IMA) and top-down proteomics (TDMS), have gained interest in recent years due to advancements in high resolution mass spectrometry instrumentation.

Updates on neonatal cell and novel therapeutics: Proceedings of the Second Neonatal Cell Therapies Symposium (2024).

Cell therapies as treatments for neonatal conditions have attracted significant research and parent interest over the last two decades. Mesenchymal stromal cells, umbilical cord blood cells and neural stem cells translate from lab, to preclinical and into clinical trials, with contributions being made from all over the world. Effective and timely translation involves frequent reflection and consultation from research-adjacent fields (i.

Time Perception and Enjoyment of Professional Soccer Players in Different Training Sessions: Implications for Assessment of Session-RPE and Training Load.

Edwards, AM, Coleman, D, Fuller, J, Kesisoglou, A, and Menting, SGP. Time perception and enjoyment of professional soccer players in different training sessions: Implications for assessment of session-RPE and training load. J Strength Cond Res 38(12): e754-e760, 2024-The purpose of this study was to investigate whether the perception of time and enjoyment levels among professional soccer players varied according to the type of training undertaken and whether this influenced the training load (TL) assessment method of session-rating of perceived exertion (sRPE).

Time Perception and Enjoyment of Professional Soccer Players in Different Training Sessions: Implications for Assessment of Session-RPE and Training Load.

Edwards, AM, Coleman, D, Fuller, J, Kesisoglou, A, and Menting, SGP. Time perception and enjoyment of professional soccer players in different training sessions: Implications for assessment of session-RPE and training load. J Strength Cond Res XX(X): 000-000, 2024-The purpose of this study was to investigate whether the perception of time and enjoyment levels among professional soccer players varied according to the type of training undertaken and whether this influenced the training load (TL) assessment method of session-rating of perceived exertion (sRPE).

Understanding the scale and nature of avoidable healthcare-associated harm for prisoners in England: protocol for a retrospective cross-sectional study.

Introduction: Around 1 in 20 patients experience avoidable healthcare-associated harm worldwide. Despite longstanding concerns, there is insufficient information available about the safety of healthcare for prisoners. To address this, this study will investigate the scale and nature of avoidable healthcare-associated harm for prisoners in England.