Publications by authors named "A Vrachliotis"
Article Synopsis
- The spline reconstruction technique (SRT) is a new, fast algorithm for analyzing small-animal PET data, specifically comparing its performance to filtered back-projection (FBP) and Tera-Tomo 3D algorithms.
- The study involved quantifying glucose metabolism in mice using Patlak graphical analysis and analyzing PET images through specialized software, determining statistical significance with one-way ANOVA.
- The results indicated no significant differences in metabolic rate measurements between SRT and the other methods, suggesting that SRT could be a suitable alternative for future preclinical PET studies.
Evaluation of the spline reconstruction technique for preclinical PET imaging.
Alexandros Vrachliotis George A Kastis Nicholas E Protonotarios Athanasios S Fokas Stephan G Nekolla
Comput Methods Programs Biomed
April 2022
Background And Objective: The Spline Reconstruction Technique (SRT) is a fast algorithm based on a novel numerical implementation of an analytic representation of the inverse Radon transform. The purpose of this study is to provide a comparison between SRT, Filtered Back-Projection (FBP), Ordered Subset Expectation Maximization 2D (2D-OSEM), and the Tera-Tomo 3D algorithm, using phantom data at various acquisition durations as well as small-animal data obtained from the Mediso nanoScan® PET/CT scanner.
Methods: For this purpose, the "NEMA NU 4-2008 standards" protocol was employed at five different realizations and acquisition durations.