Publications by authors named "A Vitucci"
Article Synopsis
- Transfusion-dependent beta thalassemia (TDT) is a genetic disorder leading to low hemoglobin levels, which can cause serious heart issues such as myocardial iron overload (MIO) and myocardial fibrosis (MF); CMR is the standard for assessing these conditions but is costly and not widely available.
- A study involving 44 TDT patients compared the effectiveness of Left Ventricular Global Longitudinal Strain (LV GLS) from Speckle Tracking Echocardiography (STE) to CMR techniques, finding that while CMR identified MIO in 18% and MF in 11% of patients, LV GLS showed significant differences based on the presence of MIO and MF.
- Results indicated that LV GLS STE could
Endothelium damage triggers the multimeric protein von Willebrand factor (VWF) release and subsequent binding to platelets, which are recruited at sites of vascular injury. A complex and fragile equilibrium between circulating levels of von Willebrand factor and its metalloprotease, ADAMTS13, is responsible for the hemostatic balance. However, the presence of autoantibodies targeting ADAMTS13 results in an increase in von Willebrand factor, mainly in its ultra-large multimers.
View Article and Find Full Text PDFWe report data on survival and complications for a longitudinal cohort of 709 transfusion-dependent β-thalassemia major patients (51.1% males) born between 1970 and 1997 and followed through 2020 at seven major centers in Italy. Overall survival probability at 30 years was 83.
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