Publications by authors named "A Vitkin"
Article Synopsis
- * It introduces reflection-mode polarimetric imaging as a method to identify non-fat regions before using a specific type of MS called picosecond infrared laser mass spectrometry (PIRL-MS), which helps avoid contamination and enhances data quality.
- * The integration of polarimetric techniques with PIRL-MS successfully identified several breast cancer markers, indicating that this combined approach can effectively optimize molecular analysis of tissues.
The editorial introduces the two-issue JBO Special Section on Polarimetry in Biomedical Optics and provides resources for further exploration.
View Article and Find Full Text PDFPreclinical intravital imaging such as microscopy and optical coherence tomography have proven to be valuable tools in cancer research for visualizing the tumor microenvironment and its response to therapy. These imaging modalities have micron-scale resolution but have limited use in the clinic due to their shallow penetration depth into tissue. More clinically applicable imaging modalities such as CT, MRI, and PET have much greater penetration depth but have comparatively lower spatial resolution (mm scale).
View Article and Find Full Text PDFSignificance: Current treatment for stage III colorectal cancer (CRC) patients involves surgery that may not be sufficient in many cases, requiring additional adjuvant systemic therapy. Identification of this latter cohort that is likely to recur following surgery is key to better personalized therapy selection, but there is a lack of proper quantitative assessment tools for potential clinical adoption.
Aim: The purpose of this study is to employ Mueller matrix (MM) polarized light microscopy in combination with supervised machine learning (ML) to quantitatively analyze the prognostic value of peri-tumoral collagen in CRC in relation to 5-year local recurrence (LR).