Publications by authors named "A Vinitsky"
Article Synopsis
- Bi-functional N-Hydroxysuccinimide (NHS) linkers are crucial in connecting immunogens with carrier proteins to enhance immune responses, particularly in HIV-1 vaccine development.
- The study investigated the degradation kinetics of these linkers using reversed-phase liquid chromatography (RPLC-UV) to ensure effective conjugation before the linkers become inactive.
- Three types of cross-linkers were examined for their degradation pathways, with specific kinetics reported for the Sulfosuccinimidyl (4-iodoacetyl) aminobenzoate (Sulfo-SIAB) linker.
Introduction: Coordinated medical evacuations represent an important strategy for emergency response when healthcare systems are impaired by armed conflict, particularly for patients diagnosed with life-threatening conditions such as cancer. In this study, we compare the experiences of two parallel medical evacuation systems developed to meet the medical needs of Ukrainians affected by war.
Methods: This retrospective study compared outcomes of two medical evacuation systems, developed by the European Union Emergency Response Coordination Centre (ERCC) and Supporting Action for Emergency Response in Ukraine (SAFER Ukraine) collaborative, in the first 10 months after the war's intensification in Ukraine (February 24 to December 21, 2022).
Background: Diffuse intrinsic pontine glioma (DIPG) is a lethal childhood cancer with median survival of less than 1 year. Panobinostat is an oral multihistone deacetylase inhibitor with preclinical activity in DIPG models. Study objectives were to determine safety, tolerability, maximum tolerated dose (MTD), toxicity profile, and pharmacokinetics of panobinostat in children with DIPG.
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- High-grade gliomas (HGG) in young children are complex and have unpredictable outcomes, necessitating further study beyond retrospective analyses.
- A study conducted at St. Jude Children’s Research Hospital analyzed a cohort of children with histologically confirmed HGG using advanced genomic profiling and imaging, leading to insights into four distinct tumor categories.
- The findings revealed that infant-type hemispheric gliomas (IHG) are the most common, especially in very young children, with significantly better survival rates compared to other types of HGG, suggesting a need for tailored therapeutic approaches.