Publications by authors named "A Vinciguerra"
Introduction: Olfactory neuroblastoma (ONB) is a rare malignant tumor originating from the olfactory neuroepithelium, typically within the sinonasal cavity. Cases of ONB originating outside of the olfactory cleft area are extremely rare and are referred to as "ectopic" (eONB), in contrast to "orthotopic" tumors (oONB). ONB has been associated with paraneoplastic syndromes (PNSs), including the syndrome of inappropriate antidiuretic hormone secretion (SIADH).
View Article and Find Full Text PDFIntroduction: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a disease with a strong impact on the quality of life (QoL) which treatment is based on local intranasal corticosteroids (ICS) and iterative courses of systemic corticosteroids (SCS) in case of relapse. When medical treatment is insufficient, surgery is indicated. We investigated the impact of enlarged frontal sinusotomies (EFS: Draf IIb or Draf III) on QoL and annual SCS consumption of patients with severe uncontrolled CRSwNP.
View Article and Find Full Text PDFArticle Synopsis
- Amyotrophic lateral sclerosis (ALS) is a progressive and currently incurable neurodegenerative disease characterized by the loss of motor neurons, muscle atrophy, and cellular dysfunction related to protein aggregation and calcium imbalances.
- Researchers have identified autophagy dysfunction as a key area for potential ALS treatment, with TRPML1 being a crucial lysosomal channel that, when properly stimulated, can aid in this process.
- A new lipid-based formulation of PI(3,5)P was developed to effectively stabilize TRPML1 activity in ALS models, showing promising results in improving neuromuscular function, reducing motor neuron loss, and extending the lifespan of SOD1 ALS mice by about 10 days.
Recurrent epistaxis, despite conservative therapies (i.e. nasal packing or direct vessel coagulation), is generally treated with ligation of the sphenopalatine artery (SPA).
View Article and Find Full Text PDFObjective: This systematic review evaluates the efficacy and morbidity of transnasal endoscopic nasopharyngectomy as a salvage treatment for advanced-stage recurrent nasopharyngeal carcinoma (rNPC).
Methods: Following PRISMA guidelines, we conducted a systematic search in Medline, Scopus, and PubMed, identifying studies on transnasal endoscopic nasopharyngectomy for rNPC. Inclusion criteria encompassed histologically confirmed rT3 and rT4 NPC patients previously treated with radiotherapy or chemoradiotherapy.