Publications by authors named "A Villar-Prados"
Allogeneic hematopoietic cell transplantation (HCT) is a curative therapy limited by graft-versus-host disease (GVHD). In preclinical studies and early-phase clinical studies enrichment of donor regulatory T cells (Tregs) appears to prevent GVHD and promote healthy immunity.We enrolled 44 patients on an open-label, single-center, phase 2 efficacy study investigating if a precision selected and highly purified Treg cell therapy manufactured from donor mobilized peripheral blood improves one-year GVHD-free relapse free survival (GRFS) after myeloablative conditioning (trial NCT01660607).
View Article and Find Full Text PDFCyclic thrombocytopenia (CTP) is characterized by periodic platelet oscillation with substantial amplitude. Most CTP cases have a thrombocytopenic background and are often misdiagnosed as immune thrombocytopenia with erratically effective treatment choices. CTP also occurs during hydroxyurea treatment in patients with myeloproliferative diseases.
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- - Paroxysmal cold hemoglobinuria (PCH) is a rare autoimmune hemolytic anemia primarily affecting children, making diagnosis and treatment difficult due to its similarity with other conditions and the limited availability of specialized tests like the Donath-Landsteiner (DL) test.
- - A retrospective study compared clinical characteristics and outcomes of PCH patients with those suffering from other forms of autoimmune hemolytic anemia, finding that DL-positive patients had elevated lactate dehydrogenase levels and reduced reticulocyte counts, although these differences were not statistically significant.
- - The study suggests a need for larger, multicenter research on PCH to enhance diagnosis and awareness of the condition, particularly in situations where DL antibody testing is not easily