Publications by authors named "A Villalonga"
Article Synopsis
- A novel sandwich-type electrochemical aptasensor was developed using a DNA aptamer and a special cyclodextrin to create a sensitive detection method for prostate-specific antigen (PSA).
- The sensor works by capturing PSA molecules on an electrode surface modified with graphene and gold, leading to a signaling response through a horseradish peroxidase complex.
- The aptasensor achieved effective detection of PSA in a range from 0.5 ng/mL to 50 ng/mL, demonstrating high selectivity and a low detection limit of 0.11 ng/mL.
The preparation of a hybrid nanomaterial is reported by covalently attaching 3,5-dinitrobenzoic acid groups to the surface of oxidized multi-walled carbon nanotubes using 1,6-diaminohexane as cross-linking agent. This nanomaterial, modified with the redox mediator, was used as transduction element to construct an amperometric sensor for the efficient indirect determination of glutathione reductase at a low working potential of - 0.05 V, through the oxidation of unconsumed nicotinamide adenine dinucleotide phosphate (NADPH) in the enzymatic reaction.
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- Patients with small-cell lung cancer (SCLC) usually have a hard time and don't get great results from current treatments.
- A new study shows that blocking a protein called ATR can help destroy cancer cells and improve the immune system's response against tumors.
- When ATR is blocked along with another treatment called PD-L1, it works better than PD-L1 alone, offering hope for new ways to help people with SCLC.
Background And Objectives: Total hip arthroplasty (THA) is an effective surgery for treating hip osteoarthritis, but access is limited in Sub-Saharan Africa due to multiple challenges. This article describes the implementation of a THA program at Monkole Hospital in the Democratic Republic of Congo, focusing on the technical challenges and surgical complications. The objective is to share our experience to assist other professionals and organizations in similar settings.
View Article and Find Full Text PDFHere, we report the preparation of a novel Janus nanoparticle with opposite Ir and mesoporous silica nanoparticles through a partial surface masking with toposelective modification method. This nanomaterial was employed to construct an enzyme-powered nanomachine with self-propulsion properties for on-command delivery. The cargo-loaded nanoparticle was provided with a pH-sensitive gate and unit control at the mesoporous face by first attaching boronic acid residues and further immobilization of glucose oxidase through reversible boronic acid esters with the carbohydrate residues of the glycoenzyme.
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