Publications by authors named "A Vilcu"
Fibrillinopathies have different phenotypic expression: Marfan-like skeleton features, MLSF; mitral valve prolapse syndrome, MVPS; MASS phenotype, M = mitral valve prolapse, MVP, A = aortic root dilation, S = skeletal features, and the second S = (cutaneous) striae; Marfan Syndrome, MS. The study had the following main objectives: the correlation between disc displacement, DD (a major sign for temporomandibular joint dysfunction, TMDs) on magnetic resonance imaging, MRI, and aortic Z score (a major sign for aortic root dilation) on echocardiography; the predictive value of DD towards aortic Z score. DD had 2 types of severity: DD with reduction (the mild type, DDwR), and DD without reduction (the severe type, DDwoR).
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- The study investigates the incidence of serious respiratory tract infections (SRI) among individuals receiving immunosuppressive therapies, using data from French healthcare between 2014-2019.
- A total of 24,122 patients were analyzed, revealing a standardized SRI incidence rate of 1,398 per 100,000 person-years, with significant associations found between SRI and various chronic conditions like cancer, respiratory diseases, and diabetes.
- It concludes that a history of chronic diseases increases the risk of SRI in patients on immunosuppressive therapies, and that this risk is lower in those treated with conventional synthetic disease-modifying anti-rheumatic drugs compared to corticosteroids.
Article Synopsis
- Recreational use of nitrous oxide (NO) has led to a rise in severe neurological disorders, particularly affecting young adults in economically disadvantaged areas.
- The study analyzed 181 patients, noting a significant incidence increase in 2020-2021, especially in those aged 20-25.
- Compared to other inflammatory neurological disorders, NI-NDs were found to be two to three times more common in these vulnerable populations.
Background: Influenza-like illness (ILI) incidence estimates in individuals treated with immunosuppressants and/or biologics and/or corticosteroid for an autoimmune or chronic inflammatory disease are scarce. We compared the ILI incidence among immunocompromised population and the general population.
Method: We conducted a prospective cohort study during the 2017-2018 seasonal influenza epidemic, on the GrippeNet.
Article Synopsis
- The study investigated the prevalence and bleeding risk associated with drug interactions between apixaban or rivaroxaban and certain CYP3A4 and P-glycoprotein inhibitors in patients with atrial fibrillation (AF).
- Using a cohort from the French healthcare database (2014-2019), 10,392 AF patients on these medications were analyzed, with a focus on hospitalization due to bleeding as the primary outcome.
- The findings revealed a 38.9% prevalence of drug-drug interactions, but no significant association with increased hospitalization for bleeding; factors like age and male gender were related to higher bleeding risk instead.