Kristen rat sarcoma viral oncogene homolog (KRAS) mutations play a major role in the carcinogenesis of many types of solid tumors including non-small cell lung cancer (NSCLC). Among KRAS mutations, p.G12C single-nucleotide variant (KRAS) is the most frequently reported in NSCLC patients, with a prevalence of about 12-13 %.
View Article and Find Full Text PDFBackground: Assessment of Progression-free survival (PFS) events by investigators might be inaccurate in randomized controlled trials (RCTs) with open-label design. We explored differences in PFS evaluated by blinded independent central review (BICR) or local investigator assessment (IA) in trials testing immunotherapy (IO) in advanced cancers.
Methods: We systematically reviewed articles of RCTs investigating IO in advanced tumors, published in PubMed-indexed journals up to December 2023.
Dissociative electron attachment rate constants have been measured for Cr(CO)6 under thermal conditions, 296-400 K, yielding Cr(CO)5- product. At 296 K, 2.92 ± 0.
View Article and Find Full Text PDFThe transfer of an oxygen atom from carbon dioxide (CO) to a transition metal cation in the gas phase offers atomic level insights into single-atom catalysis for CO activation. Given that these reactions often involve open-shell transition metals, they may proceed through intersystem crossing between different spin manifolds. However, a definitive understanding of such spin-forbidden reaction requires dynamical calculations on multiple global potential energy surfaces (PESs) coupled by spin-orbit couplings.
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