Evidence- and consensus-based guidelines for drug-drug interactions with anticancer drugs; A practical and universal tool for management.

Drug-drug interactions (DDIs) with anticancer drugs are common and can significantly affect efficacy and toxicity of treatment. Therefore, a Dutch Multidisciplinary Expert group is assessing the clinical significance of DDIs in oncology and provides recommendations for the management of these DDIs. We present an overview of methodology and outcome of an evidence- and consensus-based assessment of DDIs between anticancer drugs and non-anticancer drugs.

Islands in the oil: Quantifying salt marsh shoreline erosion after the Deepwater Horizon oiling.

Qualitative inferences and sparse bay-wide measurements suggest that shoreline erosion increased after the 2010 BP Deepwater Horizon (DWH) disaster, but quantifying the impacts has been elusive at the landscape scale. We quantified the shoreline erosion of 46 islands for before and after the DWH oil spill to determine how much shoreline was lost, if the losses were temporary, and if recovery/restoration occurred. The erosion rates at the oiled islands increased to 275% in the first six months after the oiling, were 200% of that of the unoiled islands for the first 2.

Landscape-scale analysis of wetland sediment deposition from four tropical cyclone events.

Hurricanes Katrina, Rita, Gustav, and Ike deposited large quantities of sediment on coastal wetlands after making landfall in the northern Gulf of Mexico. We sampled sediments deposited on the wetland surface throughout the entire Louisiana and Texas depositional surfaces of Hurricanes Katrina, Rita, Gustav, and the Louisiana portion of Hurricane Ike. We used spatial interpolation to model the total amount and spatial distribution of inorganic sediment deposition from each storm.

Consensus-based evaluation of clinical significance and management of anticancer drug interactions.

Background: Anticancer drug interactions can affect the efficacy and toxicity of anticancer treatment and that of the interacting drugs. However, information on the significance, prevention, and management of these interactions is currently lacking.

Objective: The purpose of this study was to assess the clinical significance of interaction among anticancer agents and comedications and to provide recommendations for the management of clinically significant interactions.

Time-dependent drug-drug interaction alerts in care provider order entry: software may inhibit medication error reductions.

Time-dependent drug-drug interactions (TDDIs) are drug combinations that result in a decreased drug effect due to coadministration of a second drug. Such interactions can be prevented by separately administering the drugs. This study attempted to reduce drug administration errors due to overridden TDDIs in a care provider order entry (CPOE) system.