Publications by authors named "A Verlinden"
Mastocytosis is a complex heterogenous multisystem disorder that is characterized by pathologic activation or accumulation of neoplastic mast cells (MCs) in one or more organs. This clonal MC expansion is often associated with a somatic gain-of-function mutation (D816V in most of the cases) in the KIT gene, encoding for the MC surface receptor KIT (CD117), a stem cell growth factor receptor. Based on clinical and biochemical criteria, the World Health Organization (WHO) divided mastocytosis into different subclasses.
View Article and Find Full Text PDFBackground: Uncertainties remain about the molecular mechanisms governing clonal mast cell disorders (CMCD) and anaphylaxis.
Objective: This study aims at comparing the burden, phenotype and behavior of mast cells (MCs) and basophils in patients with CMCD with wasp venom anaphylaxis (CMCD/WVA), CMCD patients without anaphylaxis (CMCD/ANA), patients with an elevated baseline serum tryptase (EBST), patients with wasp venom anaphylaxis without CMCD (WVA) and patients with a non-mast cell haematological pathology (NMHP).
Methods: This study included 20 patients with CMCD/WVA, 24 with CMCD/ANA, 19 with WVA, 6 with EBST and 5 with NMHP.
Background: There is currently no consensus on optimal duration of antibiotic treatment in febrile neutropenia. We report on the clinical impact of implementation of antibiotic de-escalation and discontinuation strategies based on the Fourth European Conference on Infections in Leukaemia (ECIL-4) recommendations in high-risk hematological patients.
Methods: We studied 446 admissions after introduction of an ECIL-4-based protocol (hereafter "ECIL-4 group") in comparison to a historic cohort of 512 admissions.
Article Synopsis
- A young woman developed symptoms consistent with multisystem inflammatory syndrome in adults (MIS-A) 18 days after getting her first dose of the Oxford/AstraZeneca vaccine.
- Treatment with intravenous immunoglobulins was started, resulting in her recovery.
- While the connection between the vaccine and MIS-A cannot be definitively confirmed or ruled out, the timing and absence of prior SARS-CoV-2 infection raise questions about a potential link.