Studies on tumourous and other urogenital patients with respect to antigens of oncogenic adenovirus.

The possible connection of viruses with tumours was investigated by serologic examinations. Concerning the presence of antibodies against adenoviruses, especially those against the early non-virion antigens of oncogenic adenovirus type 12, approximately 4000 tests were made with sera of 446 urogenital patients with and without tumours and 70 ones with internal diseases. It was found by complement fixation tests that antibodies against nonvirion antigens of adenoviruses were present in 53% of urogenital patients suffering from malignant tumours and prostatic hypertrophy, in 18% of non-tumourous urological patients and in 4% of patients with internal diseases, respectively.

Detection of Chlamydia trachomatis in the prostate by in-situ hybridization and by transmission electron microscopy.

Chlamydia trachomatis infection has been investigated in the prostate gland using in-situ DNA hybridization and transmission electron microscopy. Sixty-four samples of tissue removed by trans-urethral resection or by open surgery from men with benign prostatic hypertrophy (BPH), were examined histologically and 20 of the cases were found to be positive for mononuclear cell infiltration. Some samples were then investigated using in-situ hybridization and transmission electron microscopy.

Experiences on the surgical management of testicular torsion.

The authors performed operations in 9 patients at the Department of Urology of the István Hospital during the past 5 years. In 7 cases, detorsion and saving of the testicle was successful in possession of an early diagnosis. Two patients had to be castrated.

Latent virus carrying lymphocytes of patients with urological tumours.

A considerable wealth of data suggest that a virus with oncogen character can play a part in the development or survival of tumours, by disturbing immune reaction. We studied this situation in urogenital tumours. Examining the latent virus carrier with an immunofluorescent method in 96 cases with malignant tumours and 70 control cases, it was found that more than 50% of the patients had latent adeno- or herpes simplex virus antigens in 1-3% of the circulating lymphocytes, whereas virus carriers occurred in hardly a few percent in the control group.