Publications by authors named "A Venturelli"
Article Synopsis
- Thymidylate synthase (TS) is important for DNA synthesis and repair, and its overexpression contributes to drug resistance in cancer cells, particularly in ovarian and colon cancers.
- This study found that novel TS dimer disrupters (Ddis) were more effective at killing cancer cells when used alongside inhibitors of drug efflux proteins, which prevent the drugs from leaving the cells.
- The research also utilized a protein transfection agent to enhance the uptake of these Ddis, leading to reduced TS protein levels and disruptions in the cell cycle, indicating potential for improved cancer therapies.
Intersite communication in dimeric enzymes, triggered by ligand binding, represents both a challenge and an opportunity in enzyme inhibition strategy. Though often understestimated, it can impact on the in vivo biological mechansim of an inhibitor and on its pharmacokinetics. Thymidylate synthase (TS) is a homodimeric enzyme present in almost all living organisms that plays a crucial role in DNA synthesis and cell replication.
View Article and Find Full Text PDFBackground: Pseudoaneurysm (PSA) of the left ventricle (LV) is a rare peri-annular complication of infective endocarditis (IE), and it is associated with high risk of free wall rupture. The diagnosis is challenging because the exact incidence and the pathogenesis are still unclear.
Case Summary: A 69-year-old lady underwent prosthetic mitral valve replacement for IE secondary to sepsis complicated by multiple embolizations.
Article Synopsis
- Researchers identified broad-spectrum anti-infective agents from a library of 456 compounds through a high-throughput screening program, focusing on compounds effective against specific parasite species.
- Using machine learning, they characterized and synthesized 44 compounds showing strong antiparasitic properties with minimal toxicity, highlighting one promising lead with a unique chemical structure.
- The study utilized advanced chemoinformatic and machine learning tools to handle complex data, facilitating the selection and optimization of compounds for further biological and toxicological evaluation.
Policosanols (PCs) refer to a mixture of long-chain aliphatic alcohols. Sugar cane is the main industrial source of PCs, but others, including beeswax and Cannabis sativa L., are also known.
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