Publications by authors named "A Vea"
BRAF/V600E mutation and other cell growth/growth-control mechanisms are involved in naevogenesis and melanomagenesis. Immunoexpression of BRAF/V600E and other molecules (p16, phosphatase and tensin homologue (PTEN), Ki67, hTERT and Cav3.1 and 3.
View Article and Find Full Text PDF: The LRP1 (CR9) domain and, in particular, the sequence Gly-Cys (P3) plays a critical role in the binding and internalization of aggregated LDL (agLDL). We aimed to evaluate whether immunization with P3 reduces high-fat diet (HFD)-induced atherosclerosis. : Female New Zealand White (NZW) rabbits were immunized with a primary injection and four reminder doses (R1-R4) of IrP (irrelevant peptide) or P3 conjugated to the carrier.
View Article and Find Full Text PDFArticle Synopsis
- LRP1 is important for managing fat and glucose levels in the body, and its upregulation occurs in the heart during dyslipidemia.
- Researchers created a mouse model with LRP1 deficiency specifically in heart cells to study how this impacts metabolism and heart function on a high-fat diet (HFD).
- The study found that mice lacking LRP1 in cardiomyocytes maintained good heart function while resisting negative metabolic effects, linked to enhanced fat oxidation in the liver and increased signaling through ANP, highlighting the importance of LRP1 in regulating energy balance.
The role of circular RNAs (circRNAs) as biomarkers remains poorly characterized. Here, we investigated the performance of the circRNA hsa_circ_0001445 as a biomarker of coronary artery disease (CAD) in a real-world clinical practice setting. Plasma hsa_circ_0001445 was measured in a study population of 200 consecutive patients with suspected stable CAD who had undergone coronary computed tomographic angiography (CTA).
View Article and Find Full Text PDFBackground: Characterization of nevi involution could help to understand the biological behaviour of melanocytic neoplasms.
Objective: To describe the frequency and morphology of naevus involution in a series of patients with atypical naevus syndrome under digital follow-up with a SIAscopy program and, in a small sample of fading nevi, to analyse histopathological features and immunohistochemical biomarkers.
Methods: Seventy-four patients registered from April 2007 to July 2014 in the SIAscopy system of the Department of Dermatology of Hospital Arnau de Vilanova of Lleida, Spain, were reviewed.