Publications by authors named "A Van Dalem"
Aims: In recent-onset type 1 diabetes, clamp-derived C-peptide predicts good response to anti-CD3. Elevated proinsulin and proinsulin/C-peptide ratio (PI/CP) suggest increased metabolic/inflammatory beta cell burden. We reanalyzed trial data to compare the ability of baseline acutely glucose-stimulated proinsulin, C-peptide and PI/CP to predict functional outcome.
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- Chloride measurement is essential for determining the anion gap, yet bicarbonate can interfere with these measurements, leading to inaccuracies depending on the type of electrode used.
- Different electrodes showed varying levels of non-selectivity towards bicarbonate, with some becoming more biased over time while others gained selectivity.
- Adjusting calibrator bicarbonate concentrations significantly improved measurement accuracy, highlighting the need for laboratories to recognize and manage bicarbonate's impact on chloride assessments.
Objectives: When using indirect ion-selective electrode (ISE) methods, hypertriglyceridemia leads to pseudohyponatremia due to water displacement artifacts. Multiple strategies exist to minimize this interference. Our objective was to create a patient-friendly one-tube-fits-all testing setup without compromising the method robustness.
View Article and Find Full Text PDFIntroduction: The analytical and clinical performance as well as the workflow efficiency of the novel, prototype Alinity hq hematology analyzer was evaluated in the clinical laboratory of Universitair Ziekenhuis Brussel, Department of Hematology, Brussels, Belgium.
Methods: Within-run and within-laboratory imprecision, linearity, and carryover were assessed using clinical blood samples and commercial blood products. Four hundred and seventeen samples were selected for method comparison with Abbott CELL-DYN Sapphire, and for flagging performance analysis in comparison with smear review and manual microscopic white blood cell (WBC) differential.