Publications by authors named "A Vallatos"
Hypoxic ischemic encephalopathy (HIE) remains a leading cause of neonatal mortality and lifelong disability across the world. While therapeutic hypothermia (HT) is beneficial, it is only partially protective and adjuvant treatments that further improve outcomes are urgently needed. In high-income countries where HT is standard care, novel treatments are tested in conjunction with HT.
View Article and Find Full Text PDFHuman African Trypanosomiasis (HAT) is a parasitic disease originating in sub-Saharan Africa. There is limited information about the changes in the blood brain barrier (BBB) during this infection. This study is the first to apply diffusion weighted ASL (DWASL) to examine changes in BBB impairment.
View Article and Find Full Text PDFArticle Synopsis
- - Cerebral small vessel disease (SVD) causes problems in the brain, leading to memory issues and strokes, and it doesn’t always relate to high blood pressure.
- - Researchers found that a specific gene, Atp11b, is linked to brain problems in rats that mimic SVD without having high blood pressure.
- - The study suggests that differences in blood vessel cells affect how SVD develops, so treatments should focus more on these cells instead of just lowering blood pressure.
During the COVID-19 pandemic, global health services have faced unprecedented demands. Many key workers in health and social care have experienced crippling shortages of personal protective equipment, and clinical engineers in hospitals have been severely stretched due to insufficient supplies of medical devices and equipment. Many engineers who normally work in other sectors have been redeployed to address the crisis, and they have rapidly improvised solutions to some of the challenges that emerged, using a combination of low-tech and cutting-edge methods.
View Article and Find Full Text PDFBackground: Conventional MRI fails to detect regions of glioblastoma cell infiltration beyond the contrast-enhanced T1 solid tumor region, with infiltrating tumor cells often migrating along host blood vessels.
Purpose: MRI is capable of generating a range of image contrasts which are commonly assessed individually by qualitative visual inspection. It has long been hypothesized that better diagnoses could be achieved by combining these multiple images, so called multi-parametric or multi-spectral MRI.