Publications by authors named "A Valcarcel"
Article Synopsis
- The text discusses the creation of gmctool, an online tool designed to predict metabolic weaknesses in cancer cells, which is important for systems biology research.
- This tool utilizes a concept called genetic Minimal Cut Sets (gMCSs) to analyze genome-scale metabolic networks and includes a database of synthetic lethals derived from the latest metabolic map of human cells.
- Notably, gmctool has shown improved performance over earlier algorithms and has been applied to multiple myeloma, a type of blood cancer, providing experimental evidence for the critical roles of specific enzymes in certain patient groups.
Article Synopsis
- - Surgeries for abdominal wall sarcomas often involve extensive resections that create complex defects, but using both porcine dermal xenografts and composite meshes can help with repair while reducing complications.
- - A study involving 19 patients (average age 53.2 years) identified various types of sarcomas and demonstrated that surgical resections and reconstructions using these materials can be effective.
- - After an average follow-up of 38 months, complications occurred in about 31.5% of patients, including wound issues and one death, but overall, the technique showed promising medium-term results.
Alpha-Gal/α-Gal is an oligosaccharide produced by non-primate mammals. Humans have developed an immune response mediated by anti-α-Gal antibodies that can trigger an allergic reaction and cause anaphylaxis. In recent years, cases of patients with delayed allergic reaction to mammalian meat have been reported worldwide.
View Article and Find Full Text PDFSouth America is experiencing the effects of climate change, including extreme weather events and changes in temperature and precipitation patterns. These effects interact with existing social vulnerabilities, exacerbating their impact on the health and wellbeing of populations. This viewpoint highlights four main messages from the series, which presented key gaps from five different perspectives of health and climate.
View Article and Find Full Text PDFUnlabelled: Climate adaptation measures are critical for protecting human health. National Adaptation Plans (NAPs), Nationally Determined Contributions (NDCs), and National Communications (NCs) play a crucial role in helping countries identify, analyze, and address their vulnerabilities to climate change impacts, while also assessing available resources and capacities. This study aimed to assess the comprehensiveness of South American countries' NAPs, NDCs, and NCs in addressing the effects of climate change on health.
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