Publications by authors named "A Vaillo Vinagre"

Obesity, characterized by excessive fat accumulation in white adipose tissue (WAT), is linked to numerous health issues, including insulin resistance (IR), and type 2 diabetes mellitus (DM2). The distribution of adipose tissue differs by sex, with men typically exhibiting android adiposity and pre-menopausal women displaying gynecoid adiposity. After menopause, women have an increased risk of developing android-type obesity, IR, and DM2.

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Article Synopsis
  • Physical inactivity leads to insulin resistance and metabolic issues even before significant weight gain occurs.
  • Exercise performed while fasting can enhance metabolic benefits compared to exercising after eating.
  • In a study with animals, exercising while fasting resulted in lower plasma cholesterol and improved fat metabolism in brown adipose tissue, showing potential advantages of fasted exercise.
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The neuroendocrine system of crustaceans is complex and regulates many processes, such as development, growth, reproduction, osmoregulation, behavior, and metabolism. Once stimulated, crustaceans' neuroendocrine tissues modulate the release of monoamines, ecdysteroids, and neuropeptides that can act as hormones or neurotransmitters. Over a few decades, research has unraveled some mechanisms governing these processes, substantially contributing to understanding crustacean physiology.

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Biogenic amines are synthesized through the bacterial decarboxylation of amino acids, commonly found in high levels in animal by-product meals due to spoilage. Furthermore, biogenic amines and other metabolites can be produced by the fermentation of proteins in the hindgut according to the protein source and concentration of crude protein (CP) in the diet. Thus, this study aimed to evaluate two protein sources (poultry by-product meal (PBPM) and hydrolyzed chicken liver powder (HCLP)) and three CP concentrations (24, 32, and 40%) and their effects on the consumption and fecal excretion of biogenic amines, plasma monoamine oxidase (MAO) and diamine oxidase (DAO) activities, and total antioxidant capacity (TAC) of healthy adult dogs after 30 days of feeding the experimental diets.

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  • Researchers studied GAA repeat expansions in the FGF14 gene, which have been linked to spinocerebellar ataxia 27B (SCA27B), to understand its frequency and characteristics in late-onset cerebellar ataxia (LOCA) patients.
  • They screened 64 undiagnosed LOCA patients, finding that 28% had the FGF14 expansion, with gait ataxia and mild dysarthria being common symptoms.
  • The study concluded that SCA27B is the leading cause of LOCA in their patient group, suggesting FGF14 GAA expansion screening should be a standard first step in genetic testing for these patients.*
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