Publications by authors named "A VERCELLONE"
Introduction: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are rare autoimmune diseases triggering inflammation of small vessels. This real-world analysis was focused on the most common AAV forms, granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), to describe patients' demographic and clinical characteristics, therapeutic management, disease progression, and the related economic burden.
Methods: A retrospective analysis was conducted on administrative databases of a representative sample of Italian healthcare entities, covering approximately 12 million residents.
The bacterial pathogen binds to the C-type lectin DC-SIGN (dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin) on dendritic cells to evade the immune system. While DC-SIGN glycoconjugate ligands are ubiquitous among mycobacterial species, the receptor selectively binds pathogenic species from the complex (). Here, we unravel the molecular mechanism behind this intriguing selective recognition by means of a multidisciplinary approach combining single-molecule atomic force microscopy with Förster resonance energy transfer and bioassays.
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- - The study assesses a local program aimed at eliminating Hepatitis C virus (HCV) in regions with high infection rates through retrospective and prospective data analysis from a southern Italy health unit (2018-2022).
- - Findings showed that out of nearly 50,000 tested individuals, 2.2% were positive for HCV antibodies without prior RNA testing, and a notable percentage of hospital admissions involved patients with active infections and advanced liver disease.
- - The results highlight the necessity of implementing an active case-finding strategy in hospitals to improve diagnosis and link patients to care, suggesting this approach should be adopted as a standard practice in areas heavily impacted by HCV.
A consensus-based approach on the management of patients with both psoriasis and psoriatic arthritis in the dermatological and rheumatological settings in Italy: The ADOI PSO-Amore Project.
Dermatol Reports
September 2022
Article Synopsis
- Psoriasis requires a team approach for effective management, particularly involving dermatologists and rheumatologists for patients with both psoriasis and psoriatic arthritis.* -
- A group of experts has developed recommendations on when it's essential for these specialists to collaborate, either together or sequentially, based on different healthcare settings.* -
- The recommendations include organizing a joint care unit for dermatology and rheumatology, outlining a patient journey that can guide future healthcare strategies for diagnosing and treating psoriasis.*
Analysis of Patients with Focal Epilepsy and Drug-Resistant Epilepsy in Italy: Evaluation of Their Characteristics, Therapeutic Pathway and the Consumption of Healthcare Resources.
Clinicoecon Outcomes Res
July 2022
Purpose: A retrospective analysis was conducted to estimate the number of patients with focal epilepsy and drug-resistant epilepsy (DRE) and their characteristics, the therapeutic patterns, the consumption of health resources in a real-world Italian setting.
Patients And Methods: A retrospective study was carried out on the administrative databases of a sample of Italian Health Departments, covering approximately 8.7 million health-assisted individuals.