Publications by authors named "A V Yeremina"
Article Synopsis
- The study analyzed human uveal melanoma tissue samples for markers related to epithelial-mesenchymal transition (EMT) and extracellular matrix (ECM) degradation using immunohistochemical staining.
- Increased levels of EMT markers, specifically E-cadherin and vimentin, were found in the tumor tissue, suggesting changes in cell behavior.
- The imbalance in MMP-9 versus TIMP-1 proteins indicates heightened ECM degradation, potentially facilitating the invasive growth of uveal melanoma.
Uveal melanoma is an ocular tumor with a high risk of developing metastases. The endo-lysosomal system can affect the melanoma progression by accelerating and facilitating invasion or metastasis. This study aims to conduct comparative analysis of normal choroidal melanocytes and uveal melanoma cells ultrastructure with a focus on intracellular transport system, and to examine the patterns of autophagy- and vesicular trafficking-related proteins expression in a case series of uveal melanomas.
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