Transgenerational effect of prenatal stress on behavior and lipid peroxidation in brain structures of female rats during the estral cycle.

The effect of stress in pregnant female Wistar rats on the behavior and lipid peroxidation (LP) in the neocortex, hippocampus and hypothalamus in the female F2 generation during the ovarian cycle was investigated. We subjected pregnant females to daily 1-hour immobilization stress from the 15th to the 19th days of pregnancy. Further, family groups were formed from prenatally stressed and control male and female rats of the F1 generation: group 1, the control female and male; group 2, the control female and the prenatally stressed male; group 3, the prenatally stressed female and the control male; group 4, the prenatally stressed female and male.

[The effect of prenatal stress on antioxidant glutathion-assosiated enzymes activity in subcellular fractions of rat's liver].

The activity of glutathione-associated antioxidant enzymes in subcellular fractions (cytosolic, mitochondrial, and cell nucleus fractions) was investigated in the liver of adult male Wistar rats born after prenatal stress was. Two groups of animals were studied in the experiment: (1) control group included - animals was born by intact mothers, and (2) prenatal stress group included animals whose mothers were subjected to immobilization stress in high-light conditions from the 15th to the 19th day of pregnancy. The activity of glutathione peroxidase (EC 1.

Effects of prenatal stress on free-radical lipid and protein oxidation and superoxide dismutase activity in cerebral cortex neurons and neuroglia in the rat brain.

The processes of free-radical oxidation of proteins and lipids and superoxide dismutase activity were studied in neurons and neuroglia of the cerebral cortex in rats during ontogenesis and after prenatal stress. Regardless of age, normal animals were found to have higher levels of free-radical lipid and protein oxidation in neurons than in glia. This same pattern was also observed in relation to superoxide dismutase.

Protein peroxidation in the plasma of prenatally stressed rats.

We studied the effect of prenatal stress on protein peroxidation in the plasma of rats during postnatal ontogeny. Oxidative destruction of proteins in prenatally stressed rats differed from that in control animals. These differences were most pronounced in postnatal ontogeny, i.

The use of HSP70 for prevention of consequences of unavoidable stress in rats.

We studied whether intranasal treatment with HSP70 can be used for the correction of maladaptive behavior in rats after unavoidable stress. After 3 intranasal injection of HSP70 in a dose of 3.25 microg we observed normalization of adaptive behavior after unavoidable stress and improvement of physiological reserves of the organism.