Today, is still the most common cause of both local and life-threatening systemic candidiasis. The spread of resistant fungal strains has resulted in an urgent need to search for new promising antimycotics. Here, we investigated the antifungal action of the tobacco defensin NaD1 against susceptible and resistant to azoles and echinocandins strains of .
View Article and Find Full Text PDFIn recent years, additive manufacturing of products made from 5000 series alloys has grown in popularity for marine and automotive applications. At the same time, little research has been aimed at determining the permissible load ranges and areas of application, especially in comparison with materials obtained by traditional methods. In this work, we compared the mechanical properties of aluminum alloy 5056 produced by wire-arc additive technology and rolling.
View Article and Find Full Text PDFCandidiasis is one of the most common fungal diseases that can pose a threat to life in immunodeficient individuals, particularly in its disseminated form. Not only fungal invasion but also fatal infection-related inflammation are common causes of systemic candidiasis. In this study, we investigated in vitro immunomodulatory properties of the antifungal pea defensin Psd1 upon infection.
View Article and Find Full Text PDFAn increase in the frequency of mycoses and spreading of multidrug-resistant fungal pathogens necessitates the search for new antifungal agents. Earlier, we isolated the novel defensin from lentil seeds, designated as Lc-def, which inhibited the growth of phytopathogenic fungi. Here, we studied an antifungal activity of Lc-def against human pathogenic species, structural stability of the defensin, and its immunomodulatory effects that may help to prevent fungal infection.
View Article and Find Full Text PDFRationale: Stable isotope approaches are increasingly applied to better understand the cycling of inorganic nitrogen (N ) forms, key limiting nutrients in terrestrial and aquatic ecosystems. A systematic comparison of the accuracy and precision of the most commonly used methods to analyze δ N in NO and NH and interlaboratory comparison tests to evaluate the comparability of isotope results between laboratories are, however, still lacking.
Methods: Here, we conducted an interlaboratory comparison involving 10 European laboratories to compare different methods and laboratory performance to measure δ N in NO and NH .
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