[Identifying the neurostimulation target for treatment of cognitive impairment in aging and early cerebral small vessel disease].

Objective: To develop individualized approaches to the use of neuromodulation as a non-pharmacological treatment of cognitive impairment (CI) based on the assessment of compensatory brain reserves in functional MRI (fMRI).

Material And Methods: Twenty-one adults over 45 years of age, representing a continuum from healthy norm to mild cognitive impairment due to aging and early cerebral small vessel disease, were studied. All participants underwent fMRI while performing two executive tasks - a modified Stroop task and selective counting.

Levamisole-associated multifocal inflammatory encephalopathy: clinical and MRI characteristics, and diagnostic algorithm.

Levamisole-associated multifocal inflammatory encephalopathy (LAMIE) is a devastating adverse effect of levamisole (LEV) treatment. In Russia, people often use LEV without a doctor's prescription for anthelmintic prophylaxis. LAMIE often misdiagnosed as the first episode of MS or acute disseminated encephalomyelitis (ADEM).

[Acute disseminated encephalomyelitis].

Acute disseminated encephalomyelitis (AEM) is an immune-mediated inflammatory demyelinating disease of the central nervous system (CNS), usually single-phase. In WREM, multiple lesions of the central nervous system of an inflammatory-demyelinating nature accompanied by extremely polymorphic neurological disorders develop acutely or subacutely. The review considers the issues of epidemiology, trigger factors of the inflammatory process, clinical manifestations, differential and molecular diagnostics of WECM, and outlines the ways for further study of this pathology.

[YAG-Nd laser: effects of radiation on acoustic analyser function in experimental animals].

Effects of laser radiation on the function of the internal ear receptors were studied using short-latent acoustic evoked potentials (SLAEP) of rabbit truncus cerebri. Contact laser impact in the area of the medial wall of the tympanic cavity in one of the ear was made after registration of baseline SLAEP. The other ear served control.

[On surgical strategies in the treatment of patients with chronic purulent otitis media with different nature of pathology of the middle ear].

Long-term outcomes of surgery have been analysed for 684 patients with OMCP in terms of possible implications of the severity and kind of pathological processes in the middle ear as well as the operative procedure on functional and anatomic results of tympanoplasty. Early surgical interventions in OMCP are preferable because they allow "closed" tympanoplasty. Maximal removal of hypertrophic inflammation-affected parts of the tympanic mucosa promotes functional effectiveness of the operation in view of higher position of the stapes achieved with the help of combined prostheses.