Publications by authors named "A V Villarreal-Trevino"
Article Synopsis
- - The study investigates how genetic variations in the SLCO1B1 gene can influence the occurrence of adverse events (AEs) in pediatric patients with juvenile idiopathic arthritis (JIA) who are treated with methotrexate (MTX).
- - Researchers analyzed data from 30 JIA patients, finding that 66.7% experienced AEs, and identified that the *1B haplotype was common in this group, significantly increasing the risk of AEs.
- - The findings suggest that patients with the *1B allele may need lower doses of MTX to minimize AEs, and SLCO1B1 genotyping could help tailor treatment strategies to reduce risks during MTX therapy.
Article Synopsis
- The study aimed to investigate the epidemiology and outcomes of multisystem inflammatory syndrome in children (MIS-C) across 16 Latin American countries from August 2020 to June 2022.
- Out of 1239 children with MIS-C, the majority were previously healthy, with common symptoms including abdominal pain and conjunctival injection, and nearly half required intensive care.
- The overall death rate was 4.88%, notably higher for those not initially diagnosed with MIS-C, emphasizing the need for improved awareness and early detection of the syndrome.
Objectives: The aim of the study was to establish an international multicenter registry to collect data on patients with Multisystem Inflammatory Syndrome in Children (MIS-C), in order to highlight a relationship between clinical presentation, age of onset and geographical distribution on the clinical outcome.
Study Design: Multicenter retrospective study involving different international societies for rare immunological disorders.1009 patients diagnosed with MIS-C between March and September 2022, from 48 centers and 22 countries were collected.
Hematogenous spread of Neisseria gonorrhoeae, a sexually transmitted pathogen, results in disseminated gonococcal disease (DGD), also known as arthritis-dermatitis syndrome, due to the development of skin lesions, tenosynovitis, and arthritis. The most frequently affected population is young adults. We describe the case of an adolescent female who acutely developed skin lesions, arthritis, tenosynovitis, and constitutional symptoms.
View Article and Find Full Text PDFObjectives: To describe the design process of a medical care program for adolescents with pediatric onset rheumatic diseases (PRD) during the transition from pediatric to adult care in a resource-constrained hospital.
Methods: The model of attention was developed in three steps: 1) the selection of a multidisciplinary team, 2) the evaluation of the state of readiness of patients and caregivers for the transition, and 3) the design of a strategy of attention according to local needs. The results of the first two steps were used in order to develop the strategy of attention.