[Therapy of asthenic disorders after psychotic conditions in patients with cognitive impairment: results of an observational non-interventional program].

Objective: An observational non-interventional study was conducted to obtain data on the efficacy and safety of Prospekta in the treatment of postpsychotic asthenia in patients with cognitive impairment (CI).

Material And Methods: We selected 69 patients aged 18-75 years with asthenic disorders that developed after suffering psychotic conditions and CI, who were prescribed Prospekta. At four visits (at baseline, after 2, 4 and 8 weeks), the doctor collected complaints, anamnesis, examined the patient, assessed the severity of asthenia on the MFI-20 (The Multidimensional Fatigue Inventory-20) scale, CI - on the MMSE (The Mini-mental state examination).

[A comparative study of different types of pharmacotherapy in treatment of depressive phase of bipolar II disorder].

Objective: A comparative evaluation of the efficacy and safety of different types of pharmacotherapy: antidepressant monotherapy (agomelatine or sertraline), mood stabilizer monotherapy (valproate) and combination therapy (valproate + sertraline) in bipolar II disorder patients with major depressive episode.

Material And Methods: A 6-week open randomized study included 89 inpatients and outpatients. Basic criteria of efficacy were ≥50% reduction of HAMD total score and remission (≤7 points) to the end of the study.

Bipolar II disorder in patients with a current diagnosis of recurrent depression.

Objectives: The prevalence of bipolar II disorder (BD-II) in Russia has never been studied. Therefore, we sought to identify patients meeting diagnostic criteria for BD-II among patients with a current diagnosis of recurrent depressive disorder (RDD) through the use of the Russian versions of the Hypomania Checklist (HCL-32) and Bipolarity Index scales for differentiating between BD-II and RDD.

Methods: In a non-interventional diagnostic study, we selected 409 patients aged between 18 and 65 years from two medical settings with (i) a current diagnosis of RDD, (ii) an illness duration of at least three years, and (iii) at least two affective episodes.

Validation of the Russian version of the Hypomania Checklist (HCL-32) for the detection of Bipolar II disorder in patients with a current diagnosis of recurrent depression.

Background: There are no validated screening tools for Bipolar Disorder (BD) in Russia.

Objective: To validate the Russian version of the HCL-32 for the detection of Bipolar II disorder (BD II) in patients with Recurrent Depressive Disorder (RDD).

Methods: 409 patients with a current diagnosis of RDD were recruited.

[Modern treatment of a depressive phase (review)].

The analysis of modern Russian and world literature on the diagnosis and treatment of a depressive phase of bipolar affective disorder (BAD) is presented. Studies on the efficacy of different groups of drugs (antidepressants, mood stabilizers, antipsychotics) used in the treatment of bipolar disorders are reviewed. Expert views on the treatment of bipolar disorders are discussed.