Publications by authors named "A V Tyakht"
This study investigated the relationship between gut microbiota and neuropsychiatric disorders (NPDs), specifically anxiety disorder (ANXD) and/or major depressive disorder (MDD), as defined by Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV or V criteria. The study also examined the influence of medication use, particularly antidepressants and/or anxiolytics, classified through the Anatomical Therapeutic Chemical (ATC) Classification System, on the gut microbiota. Both 16S rRNA gene amplicon sequencing (16S) and shallow shotgun sequencing (WGS) were performed on DNA extracted from 666 fecal samples from the Tulsa-1000 and Neurocomputational Mechanisms of Affiliation and Personality Study Center for Biomedical Research Excellence (NeuroMAP CoBRE) cohorts.
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- Sequence-based analysis of the microbiomes in fermented foods and beverages sheds light on their effects on taste and health, using advanced metagenomics techniques for detailed profiling.
- A new Hi-C metagenomics pipeline was developed for analyzing spontaneously fermented beers and ciders, resulting in improved genome reconstruction of the bacterial and yeast populations involved.
- Findings revealed significant diversity in microbial communities, particularly in Lactobacillaceae for beers and Brettanomyces and Saccharomyces for ciders, highlighting potential health benefits and niche adaptations of these organisms within their environments.
This study investigated the relationship between gut microbiota and neuropsychiatric disorders (NPDs), specifically anxiety disorder (ANXD) and/or major depressive disorder (MDD), as defined by DSM-IV or V criteria. The study also examined the influence of medication use, particularly antidepressants and/or anxiolytics, classified through the Anatomical Therapeutic Chemical (ATC) Classification System, on the gut microbiota. Both 16S rRNA gene amplicon sequencing and shallow shotgun sequencing were performed on DNA extracted from 666 fecal samples from the Tulsa-1000 and NeuroMAP CoBRE cohorts.
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- The study highlights the ability to create various biologically active molecules, notably xylomannan and fucogalactan, which have potential anticancer properties, and points out the genetic variability among species affecting metabolite production.
- The researchers used high-throughput shotgun sequencing to fully sequence the genome of strain 5.1, known for its xylomannan production, successfully enhancing the genome assembly to create 12 chromosome-level scaffolds.
- The resulting genome sequence not only aids in understanding the biological mechanisms behind the species' medicinal use but also contributes to knowledge about fungal genomics and polysaccharide biosynthesis.
The gut microbiome plays a pivotal role in the human body, and perturbations in its composition have been linked to various disorders. Stability is an essential property of a healthy human gut microbiome, which allows it to maintain its functional richness under the external influences. This property has been explored through two distinct methodologies - mathematical modelling based on ecological principles and statistical analysis drawn from observations in interventional studies.
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