Modelling business processes in palliative care management: ways to optimise resource management.

Objective: Aim: To evaluate the impact of corrective coefficients on the income of multidisciplinary mobile palliative care teams (MMPCT) in Ukraine under different scenarios, such as new contracts, patient count, and service cost variability, to identify optimization pathways for resource management in palliative care.

Patients And Methods: Materials and Methods: A comprehensive literature review was conducted, including sources from JAMA Scholar and PubMed. The Monte Carlo method simulated 10 000 scenarios of uncertainty, such as patient count and diagnoses, to assess the effect of corrective coefficients.

Hit optimization by dynamic combinatorial chemistry on energy-coupling factor transporter ECF-PanT.

Herein, we present the first application of target-directed dynamic combinatorial chemistry (tdDCC) to the whole complex of the highly dynamic transmembrane, energy-coupling factor (ECF) transporter ECF-PanT in . In addition, we successfully employed the tdDCC technique as a hit-identification and -optimization strategy that led to the identification of optimized ECF inhibitors with improved activity. We characterized the best compounds regarding cytotoxicity and performed computational modeling studies on the crystal structure of ECF-PanT to rationalize their binding mode.

Identification of inhibitors targeting the energy-coupling factor (ECF) transporters.

The energy-coupling factor (ECF) transporters are a family of transmembrane proteins involved in the uptake of vitamins in a wide range of bacteria. Inhibition of the activity of these proteins could reduce the viability of pathogens that depend on vitamin uptake. The central role of vitamin transport in the metabolism of bacteria and absence from humans make the ECF transporters an attractive target for inhibition with selective chemical probes.

THE AVAILABILITY AND QUALITY OF PALLIATIVE AND HOSPICE CARE ENSURING IN THE COVID-19 PANDEMIC CONTEXT.

Objective: The aim: To study the availability, quality and features of outpatient palliative and hospice care (PHC) to the population, including the elderly, in the COVID-19 pandemic context in order to optimize the PHC-mobile-teams service.

Patients And Methods: Materials and methods: Domestic and foreign literary sources; sociological research results. The research methods: biblio-semantic, sociological (questionnaires), systemic approach and systemic analysis, conventional medical-statistical methods.