Publications by authors named "A V Trufanova"
Unsaturated fatty acids, such as oleic acid (OA) and linoleic acid (LA), are promising antimicrobial and cytostatic agents. We modified OA and LA with thymol (TOA and TLA, respectively) to expand their bioavailability, stability, and possible applications, and encapsulated these derivatives in polymeric nanoparticles (TOA-NPs and TLA-NPs, respectively). Prior to synthesis, we performed mathematical simulations with PASS and ADMETlab 2.
View Article and Find Full Text PDFArticle Synopsis
- A study involving 5,340 residents of Moscow investigated the relationship between immune responses (antibodies and T cells) to SARS-CoV-2 and the likelihood of COVID-19 infection.* -
- Results showed that individuals with both high T-cell and antibody responses had the lowest risk of infection, while those with only an antibody response also had a strong protective effect.* -
- The findings highlight that antibody responses are more crucial for protection against SARS-CoV-2 compared to T-cell responses, suggesting potential implications for public health policies related to COVID-19.*
Tripeptide Pro-Gly-Pro interacted with dopamine receptors in vitro and reduced behavioral manifestations of apomorphine-induced hyperfunction of the dopamine system in verticalization, stereotypy, and yawning tests. Presumably, the behavioral effects of Pro-Gly-Pro tripeptide were mediated through post- and presynaptic D(2)and D(3)receptors.
View Article and Find Full Text PDF[Study of gly-proline-containing peptides (PGP and GPGPGP) degradation by aggressive factors in vitro].
Eksp Klin Gastroenterol
October 2011
PGP, as well as GPGPGP remain stable after 24-hour incubation in a proteolytic environment (in vitro), like equine and rat gastric juice, hydrochloric acid and pepsin in the solution of hydrochloric acid. Perhaps the appearance of PGP's metabolites--PG and GP, that found in the stomachic tissues, is associated with the action of tissue and blood peptidases. Thus, the effects of PGP and GPGPGP cause by the influences both of the peptides and their metabolites, that agree with previously results.
View Article and Find Full Text PDFGlyprolines (PGP, GPG, GPGP, PGPGP, and GPGPGP) modulated histomorphological characteristics of acetate ulcers. They accelerated healing of acetate ulcers, promote complete differentiation of the surface epithelium and glands in the gastric mucosa, contributed to the appearance of a considerable number of fibroblasts at the site of the regenerating mucosa, and significantly decreased the count of macrophages.
View Article and Find Full Text PDF