Pre-Holocene Taymyr Mammoth Petya: Mineralogical, Isotope, and Geochemical Properties of Bones, Soft Tissues, Skin, and Hair and Paleoecological Reconstructions.

New remains of a Taymyr mammoth, including bones, bone collagen, hairs, skin, and soft (muscle and fat) tissues were studied comprehensively by mineralogical, spectroscopic, chromatographic, and isotope-geochemical methods. The results were used to infer the mammoth's biological age and diet, paleoclimatic conditions, and the mechanisms and degree of fossilization of the remains.

Risankizumab for the Treatment of Moderate to Severe Plaque Psoriasis in the Russian Federation.

Introduction: Risankizumab has demonstrated efficacy and safety in phase 3 studies in patients with moderate to severe plaque psoriasis. This randomized clinical trial assessed the efficacy and safety of risankizumab in patients with moderate to severe plaque psoriasis in the Russian Federation.

Methods: Patients with moderate to severe plaque psoriasis were randomized 4:1 to 16 weeks of double-blind treatment with risankizumab 150 mg or placebo (period A; dosing at baseline and week 4) followed by an open-label extension (period B) during which all patients received risankizumab 150 mg at weeks 16, 28, and 40 and were followed up to week 52.

TROPHY registry - status report.

Introduction: The TROPHY registry has been established to conduct an international multicenter prospective data collection on the surgical management of neonatal intraventricular hemorrhage (IVH)-related hydrocephalus to possibly contribute to future guidelines. The registry allows comparing the techniques established to treat hydrocephalus, such as external ventricular drainage (EVD), ventricular access device (VAD), ventricular subgaleal shunt (VSGS), and neuroendoscopic lavage (NEL). This first status report of the registry presents the results of the standard of care survey of participating centers assessed upon online registration.

A Structural Model of the Inactivation Gate of Voltage-Activated Potassium Channels.

After opening, the Shaker voltage-gated potassium (K) channel rapidly inactivates when one of its four N-termini enters and occludes the channel pore. Although it is known that the tip of the N-terminus reaches deep into the central cavity, the conformation adopted by this domain during inactivation and the nature of its interactions with the rest of the channel remain unclear. Here, we use molecular dynamics simulations coupled with electrophysiology experiments to reveal the atomic-scale mechanisms of inactivation.