[Micellar laccase-catalyzed synthesis of electroconductive polyaniline].

A method of enzymatic synthesis of electroconductive polyaniline on the micelles of dodecylben-zenesulfonic acid sodium salt (DBSNa) is proposed. The high potential laccase from the basidiomycete Trametes hirsuta was used as a biocatalyst. The conditions for polyaniline synthesis were optimized (pH 4.

[Clinico-pharmacological study of a new Russian anti-angina preparation dinitrosorbilong].

Eighty patients with ischemic heart disease and stable angina pectoris of effort were examined for the efficacy of dinitrosorbilong (DNL), a new long-acting drug based on isosorbide dinitrate (ID). The anti-ischemic effect of DNL appraised with the aid of repeated exercise lasted about 8h, which was on the average 4 h longer as compared with the duration of the anti-ischemic effect of ID tablets. The regular intake of DNL favoured an appreciable decrease in the number of angina pectoris attacks making it possible to lower nitroglycerin consumption.

[Possibility of developing tolerance to the anti-anginal effect of isosorbide dinitrate and verapamil].

Using exercise tests in 22 patients with stable angina of effort, the authors studied the possibility of the development of tolerance to the antianginal effect of isosorbide dinitrate (ID) and verapamil (VP). Within 6-12 weeks of the regular intake of ID, 5 (26%) patients developed complete tolerance, 6 (32%) partial tolerance to the drug. In 8 (42%) patients the effect of ID remained stable.

[Tolerance for the antianginal effect of nitrates. Approaches to its study].

Fifteen patients with coronary heart disease and stable angina pectoris of effort were examined for tolerance to the antianginal effect of isosorbide dinitrate (ID) taken permanently. After 6 weeks of treatment with ID in doses selected on an individual basis the antianginal effect evaluated by bicycle ergometry before and after ID intake remained stable. Sixty per cent of the patients showed a decrease in the drug effect, while in 40 per cent of the patients that decrease was moderate (partial ID tolerance) and in 20 per cent considerable (marked ID tolerance).