Lensless optical encryption with speckle-noise suppression and QR codes.

The majority of contemporary optical encryption techniques use coherent illumination and suffer from speckle-noise pollution, which severely limits their applicability even when information encoded into special "containers" such as a QR code. Spatially incoherent encryption does not have this drawback, but it suffers from reduced encryption strength due to formation of an unobscured image right on top of the encrypted one by undiffracted light from the encoding diffraction optical element (DOE) in axial configuration. We present a new lensless encryption scheme, experimentally implemented with two liquid crystal spatial light modulators, that does not have this disadvantage because of a special encoding DOE design, which forms desired light distribution in the photosensor plane under spherically diverging illumination without a converging lens.

Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.

The design and synthesis of a new series of potent non-prostanoid IP receptor agonists that showed oral efficacy in the rat monocrotaline model of pulmonary arterial hypertension (PAH) are described. Detailed profiling of a number of analogues resulted in the identification of 5c (ralinepag) that has good selectivity in both binding and functional assays with respect to most members of the prostanoid receptor family and a more modest 30- to 50-fold selectivity over the EP3 receptor. In our hands, its potency and efficacy are comparable or superior to MRE269 (the active metabolite of the clinical compound NS-304) with respect to in vitro IP receptor dependent cAMP accumulation assays.