Experimental Examination of Solubility and Lipophilicity as Pharmaceutically Relevant Points of Novel Bioactive Hybrid Compounds.

The important physicochemical properties of three novel bioactive hybrid compounds with different groups (-CH, -F and -Cl) were studied, including kinetic and thermodynamic solubility in pharmaceutically relevant solvents (buffer solutions and 1-octanol) as well as partition coefficient in system 1-octanol/buffer pH 7.4. The aqueous solubility of these chemicals is poor and ranged from 0.

Protocol of conjugate evaluation of the biological activity of soils in terms of cellulolytic activity and biological consumption of oxygen.

The article presents protocols for determining the biological activity of kerosene-contaminated soils in terms of two indicators, i.e. cellulolytic activity and biological consumption of oxygen.

The Influence of Kerosene on Microbiomes of Diverse Soils.

One of the most important challenges for soil science is to determine the limits for the sustainable functioning of contaminated ecosystems. The response of soil microbiomes to kerosene pollution is still poorly understood. Here, we model the impact of kerosene leakage on the composition of the topsoil microbiome in pot and field experiments with different loads of added kerosene (loads up to 100 g/kg; retention time up to 360 days).

The Effect of Kerosene Pollution on the Cellulolytic Activity of Albic Retisols and Arenosols (Aridic): A Laboratory Experiment.

Unlabelled: The results of a laboratory experiment modeling the effect of kerosene contamination on the cellulolytic activity of microbiocenosis of the Albic Retisol (Kaluga oblast, Russia) and Arenosol (Kyzylorda oblast, Republic of Kazakhstan) humus horizons are described. Cellulolytic activity is assessed according to the rate of weight loss in linen cloth fragments during the incubation for 0-3, 3-7, and 7-13 months. The intensity of cellulolytic activity in the unpolluted Albic Retisol is higher as compared with the Arenosol, which is determined by low acidity and an elevated content of organic matter and nutrients.