[Role of intraepithelial lymphocytes in the development of bladder tumors].

Morphometry of lymphocytic infiltration of bladder tumour parenchyma was performed. In human bladder tumours, the positive correlation between the number of intraepithelial lymphocytes and stages of tumour progression was found. The same correlation between the degree of lymphocytic infiltration of tumour parenchyma and the rate of tumour cell proliferation was observed when historadioautographs of experimental rat bladder neoplasms were analysed.

[Use of lymphocytic DNA by the urothelium of bladder tumors].

In 35 rats tumors of the urinary bladder were induced by nitrosomethylurea. A rubber loop was established on the neck of the urinary bladder and tightened for 1.5 h.

[Degree of lymphocytic infiltration of the epithelium in bladder tumors].

Lymphocytic infiltration of parenchyma and stroma of transitional cell tumors of human urinary bladder was assessed separately by quantitative morphometric procedures. The study established an increased level of lymphocytic infiltration of urothelium in areas adjacent to tumor matched by a relevant decrease in simple papillomas. Infiltration level remained unchanged in proliferating papillomas and papillomas with multiple carcinomas in situ.