Intranasal Administration of the Combination of Dextro-Ketamine and Dexmedetomidine for Treatment of Diabetic Neuropathic Pain in Rats.

Introduction: Diabetes mellitus (DM) has become a public health problem, which is associated with high morbidity and mortality, due to the chronic complications, such as diabetic neuropathy. Current recommendations for the treatment of neuropathic pain achieve a reduction of 30% in only 30% of cases. Therefore, it is necessary to identify new therapeutic approaches to improve the quality of life of diabetic patients.

Effectiveness of Body Remodeling and Cellulite Appearance Improvement Treatments in the Thighs Using Symmed Radiofrequency Device.

Background: Aging associated with the passage of time causes alterations in subcutaneous tissues and the overall appearance of the skin that generate aesthetic unconformities in people. Within the wide range of available techniques on the market, radiofrequency (RF) diathermy has emerged as one of the most used non-invasive methods to combat them.

Objective: This clinical trial aims to determine and quantify the effectiveness and safety of the high-frequency RF-based device Symmed (Termosalud Inc.

Reach and engagement on the history of nursing on social media in light of Pierre Lévy.

Objective: To analyze the reach and engagement on the history of nursing on social media of the Memory Center of the School of Nursing, Federal University of Minas Gerais (CEMENF/UFMG), in light of Pierre Lévy.

Methods: Documentary study carried out on CEMENF's Instagram and on the YouTube of the School of Nursing of UFMG, from September to December 2021. The findings were analyzed according to Pierre Lévy's concepts.

Inhibitory Effect on the Tyrosinase Activity and Low Cytotoxicity of Monounsaturated Long-Chain Chelating Fatty Ester.

In the present study, 5-Hydroxy-2-(Oleoyloxymethyl) -4H-pyran-4-one (KMO 3), and their chelated with Cu(II) and Fe(III) ions were synthesized to explore their inhibitory activity against tyrosinase and cytotoxicity. To this end, the structures of the obtained compounds were confirmed by ATR/FT-IR, 13C and 1H-NMR, and UV-vis techniques. The results show that chelating fatty ester presents the bands at 1567m, 1511w cm-1 attributed to the coordinated carbonyl (Cu(II)←[O=C]2), and the bands at 1540m, 1519m cm-1 which were attributed to the coordinated carbonyl (Fe(III)←[O=C]3).

Molecular markers and cytogenetics of Eleven O'Clock Portulaca umbraticola: a non-conventional edible ornamental crop.

Portulaca umbraticola, commonly known as "Eleven o'clock", is a popular ornamental plant in Brazil, but its potential as a non-conventional food source remains underexplored. Assessing its genetic and cytogenetic diversity is crucial for breeding and selecting optimal accessions. In this study, we analyzed the genetic diversity of P.