Publications by authors named "A V Sanin"

Article Synopsis
  • Ongoing outbreaks of various viral infections highlight the urgent need for new antiviral compounds, with a focus on immunomodulatory drugs due to the immunotoxic properties of many viruses.
  • A synthetic compound related to indole-3-carboxylic acid derivatives (referred to as XXV) has been developed, demonstrating antiviral and interferon-inducing activities in a macrophage-like cell model.
  • The study utilized real-time PCR to show that XXV significantly stimulates the expression of toll-like receptors, interferons, and cytokines, indicating its role as an activator of innate immunity and its potential in fighting viral pathogens.
View Article and Find Full Text PDF
Article Synopsis
  • Glioblastoma (GBM) is a highly aggressive brain tumor, with a subtype called mesenchymal (MES-GBM) known for its resistance to treatment.
  • Trihexyphenidyl (THP), an existing medication, has been shown to effectively inhibit the growth and survival of MES-GBM cells while sparing non-tumor cells.
  • The study suggests THP's potential for repurposing as a cancer treatment, but more research is needed to clarify its mechanisms of action and establish optimal treatment protocols.
View Article and Find Full Text PDF

Piezoelectric detectors are integral part of modern ultrasound imaging systems. Their utility has also been extended beyond the established methodologies into the emerging realm of hybrid optoacoustic imaging. Conventional piezoceramic detectors, however, struggle to combine high detection sensitivity with ultrawide bandwidth, both considered critical for attaining optimal optoacoustic imaging performance.

View Article and Find Full Text PDF

Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most difficult to treat tumors. The Src (sarcoma) inhibitor dasatinib (DASA) has shown promising efficacy in preclinical studies of PDAC. However, clinical confirmation could not be achieved.

View Article and Find Full Text PDF

The discovery and optimization of new materials for energy storage are essential for a sustainable future. High-throughput experimentation (HTE) using a scanning droplet cell (SDC) is suitable for the rapid screening of prospective material candidates and effective variation of investigated parameters over a millimeter-scale area. Herein, we explore the transition and challenges for SDC electrochemistry from aqueous toward aprotic electrolytes and address pitfalls related to reproducibility in such high-throughput systems.

View Article and Find Full Text PDF