Do Brazilian Olympic athletes live longer than the general population? A retrospective cohort study.

We investigated if Brazilian Olympic athletes live longer than the general population, and if there are differences between the types of sport. This is a retrospective cohort study with secondary data analysis. Data from Brazilian athletes of both sexes were included, from the 7th edition (1920) to the 25th edition (1992) of the Modern Olympic Games.

Epiphora associated with anomalies of the distal end of the nasolacrimal duct in children over 12 months: endoscopic findings and treatment.

Purpose: Congenital epiphora can be related to anomalies of the nasolacrimal duct. This study aimed to assess the distal end of the nasolacrimal duct and the outcomes of endoscopic treatment in children older than 12 months with congenital epiphora.

Methods: This retrospective analysis describes the clinical characteristics, management, and outcomes of symptomatic congenital lacrimal obstruction in 32 lacrimal systems of 23 children.

New insight on the acute CCl-induced hepatotoxicity model in rats.

The CCl-induced hepatotoxicity model is a traditional preclinical assay applied to evaluate potential hepatoprotective compounds. However, several studies have used it with inappropriate dose and exposure time, generating both weak response or irreversible liver injury, as well as lack of representative liver and plasma biomarkers. Therefore, this study aims to determine the best dose and exposure time of CCl in Wistar rats, permitting a proper evaluation of potential hepatoprotective effect.

Performance of Extracellular Vesicles From () for Serological Diagnosis of Human and Canine Visceral Leishmaniasis.

Visceral leishmaniasis (VL) is a zoonotic disease in which dogs are the main reservoirs. Until now, the serological tests do not present satisfactory sensitivity for diagnosis of these hosts. One of the functions of extracellular vesicles (EVs) is related to immunological host response.

Analysis of MLKL, RIP1 and RIP3 Immunostaining Markers in Human Liver Tissue from Fatal Yellow Fever Cases: Insights into Necroptosis.

Necroptosis is a regulated form of cell death implicated in several pathological conditions, including viral infections. In this study, we investigated the expression and correlation of necroptosis markers MLKL, RIP1 and RIP3 in human liver tissue from fatal cases of yellow fever (YF) using immunohistochemistry (IHC). The liver samples were obtained from 21 YF-positive individuals and five flavivirus-negative controls with preserved liver parenchymal architecture.